Jika dikonsumsi bersama sildenafil, bosentan dapat menurunkan kadar konsentrasi plasma sildenafil pada tubuh secara signifikan sehingga pengobatan berjalan kurang efektif. Konsumsi sildenafil bersama nitrat seperti nitroglycerin dapat menyebabkan penurunan tekanan darah yang signifikan sehin

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